The University of Chicago Medical Center this week announced 450 layoffs of non-physician positions as part of a restructuring aimed at trimming $100 million in costs.

The hospital said it planned to cut other positions among its workforce of 10,000 through attrition over the next 18 months. UCMC is coping with a decline in admissions and increased costs. Although officials expect hospital operations to remain profitable, margins have narrowed.

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