CHICAGO — Rochester, Minn.-based Mayo Clinic will enter the market Wednesday and shift $290 million of variable-rate securities to a fixed-rate structure to open up room in its debt portfolio for future floating-rate debt that would finance two proton therapy centers.

Bank of America Merrill Lynch and Wells Fargo Securities are the underwriters, Morgan Keegan & Co. is financial adviser and Dorsey & Whitney LLP is bond counsel. Rochester is serving as conduit issuer for the prestigious medical system.

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